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New study demonstrates viral family targeted by the immune response to Kawasaki disease

BALTIMORE – A new study identifies antigens targeted by the antibody response of children with Kawasaki Disease (KD). Findings will be presented during the Pediatric Academic Societies (PAS) 2019 Meeting, taking place on April 24 – May 1 in Baltimore.

“To identify antigens targeted by the antibody response of children with KD, we identified plasmablasts that were clonally expanded in the peripheral blood of 11 children with KD and made monoclonal antibodies from these plasmablasts,” said Anne Rowley, MD, one of the authors of the study. “Monoclonal antibodies from nine of the 11 patients identified intracytoplasmic inclusion bodies in ciliated bronchial epithelium of fatal KD cases. A subset of these antibodies recognizes peptides from a hepacivirus non-structural protein, and an optimized peptide blocked binding of these antibodies to the inclusion bodies, demonstrating the presence of a hepacivirus-like protein in the inclusion bodies. These results strongly suggest that a new human virus, closely related to the hepaciviruses and with a respiratory portal of entry, is etiologically related to KD.”

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New study aims to better understand Kawasaki disease

BALTIMORE – A new study looks to define the antibody characteristics, including clonality, of plasmablasts during Kawasaki Disease (KD). Findings from the study will be presented during the Pediatric Academic Societies (PAS) 2019 Meeting, taking place on April 24 – May 1 in Baltimore.

“We still don’t know the cause of KD, the leading cause of childhood acquired heart disease in developed nations,” said Mark Hicar, MD, PhD, one of the authors of the study. “During a normal infectious immune response, special B cells called plasmablasts that are specific to the infection are found in the peripheral blood. We are characterizing these responses in a number of children with KD, have created antibodies from these plasmablasts, and are using these to identify the cause of KD.”

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Groundbreaking research at Seattle Children’s Hospital to help diagnose rare health condition

SEATTLE – A groundbreaking researching happening right here in Washington is giving doctors new hope at better treating and diagnosing a rare health condition called Kawasaki disease. It’s a rare inflammatory condition that mostly affects children under 5.

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Etanercept With IVIg for Acute Kawasaki Disease: A Randomized Controlled Trial

Dr. Michael A. Portman and colleagues have published the results of a clinical trial showing benefits by etanercept (brand name Enbrel) for Kawasaki Disease patients. The results were published in the American Academy of Pediatrics journal Pediatrics. The manuscript abstract and publicly available video abstract describing the study can be found via the link below.

For questions and participation in Kawasaki Disease research please email KawasakiDisease@seattlechildrens.org

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Treatment Intensification in Patients With Kawasaki Disease and Coronary Aneurysm at Diagnosis

Coronary artery aneurysms (CAA) are a serious complication of Kawasaki disease. Treatment with intravenous immunoglobulin (IVIg) within 10 days of fever onset reduces the risk of CAA from 25% to <5%. Corticosteroids and infliximab are often used in high-risk patients or those with CAA at diagnosis, but there are no data on their longer-term impact on CAA.

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Fever, conjunctivitis, rash, and belly pain

KD case study written by two medical doctors highlights that children with KD and prominent GI (gastrointestinal (GI) symptoms of abdominal pain and diarrhea) or hepatobiliary (having to do with the liver plus the gallbladder, bile ducts, or bile) involvement appear to be at a higher risk for IVIG failure. Furthermore, ultrasound findings of gall bladder disease in the acute phase of KD, especially the presence of gall bladder distention, might be an important risk factor for coronary artery abnormalities as a complication.

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Researcher: Kawasaki Disease Spike In San Diego Likely Tied To Aerosol Particles

An unusual and potentially deadly disease is making a growing number of San Diego County children sick, and researchers say it’s caused by something in the air. When 3-year-old Amelia Hurvitz was admitted to Rady Children’s Hospital in February, the toddler, with curly blond hair, had a high fever, swollen lymph nodes in her neck and red, cracked lips. “She started having the rash, she started having red hands and feet that were swelling a little bit, and then her eyes were getting very bloodshot,” said Amelia’s mom, Laura Hurvitz.

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